Fresh analysis suggests that people who discontinue blockbuster GLP-1 drugs like Wegovy and Mounjaro may regain shed pounds far faster than those who stop traditional lifestyle plans.
Findings released in a prominent medical journal shows that while obese people can lose a large proportion of their total mass while using the jabs, the weight is regained at an average rate of 0.8 kg per month after stopping.
"Individuals buying such treatments should be informed of the danger of fast rebound weight gain when the medication is stopped," warns expert Dr. Susan Jebb.
This pace of recovery suggests a return to original mass within about a year and a half.
Comparing Therapies
The research, which reviewed dozens of trials involving over 9,000 of patients, contrasted the results of GLP-1 agonists with other pills.
Scientists emphasize that individuals who lose weight through dieting typically experience a slower weight regain—around 0.1 kg a month—once they finish.
Explaining the Fast Regain
Nutrition scientists propose the mode of action of the jabs is key to understanding the amplified weight return.
GLP-1 drugs mimic a body's own chemical called GLP-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 concentrations far above than normal could lead to the system to generate a reduced amount of its own natural hormone, and could lessen sensitivity to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this GLP-1 'fix' results in appetite is uncontrolled, making overeating much more probable."
A Lifelong Disease?
The NHS suggest the injections for individuals with weight-linked health risks, accompanied by recommended lifestyle changes.
Many experts contend that, given the likelihood of relapse, the treatment might need to be long-term.
This perspective is supported by pharmaceutical companies, who state that the results "emphasize the persistent character of excess weight," akin to managing diseases like high blood pressure.
Patient Experiences
Users who have discontinued the jabs report a sudden return of hunger.
"It felt as if a trigger flipping and you become extremely hungry," said an individual.
The struggle is compounded if patients have not established lasting lifestyle or habit changes during treatment.
Growing Adoption
Recent estimates indicate that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is higher among females than males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than public health services.
In conclusion, clinicians emphasize that while the jabs are potent tools for weight loss, they are not a magic cure and lasting health benefits likely depends on integrated behavioural support.
